Sensitive automated ELISA for measurement of vitamin D-binding protein (Gc) in human urine.
نویسندگان
چکیده
an Italian multicentre study. Italian Society of Paediatric Gastroenterology and Hepatology (SIGEP) and “Club del Tenue” Working Groups on Coeliac Disease. Gut 1998;42:362–5. 4. Collin P, Maki M, Keyrilainen O, Hallstrom O, Reunala T, Pasternack A. Selective IgA deficiency and coeliac disease. Scand J Gastroenterol 1992; 27:367–71. 5. Hill PG, Forsyth JM, Semeraro D, Holmes GK. IgA antibodies to human tissue transglutaminase: audit of routine practice confirms high diagnostic accuracy. Scand J Gastroenterol 2004;39:1078–82. 6. Van Meensel B, Hiele M, Hoffman I, Vermeire S, Rutgeerts P, Geboes K, et al. Diagnostic accuracy of ten second-generation (human) tissue transglutaminase antibody assays in celiac disease. Clin Chem 2004;50:2125–35. 7. Rittmeyer C, Rhoads JM. IgA deficiency causes false-negative endomysial antibody results in celiac disease. J Pediatr Gastroenterol Nutr 1996;23: 504–6. 8. Bazzigaluppi E, Lampasona V, Barera G, Venerando A, Bianchi C, Chiumello G, et al. Comparison of tissue transglutaminase-specific antibody assays with established antibody measurements for coeliac disease. J Autoimmun 1999;12:51–6. 9. Korponay-Szabo IR, Dahlbom I, Laurila K, Koskinen S, Woolley N, Partanen J, et al. Elevation of IgG antibodies against tissue transglutaminase as a diagnostic tool for coeliac disease in selective IgA deficiency. Gut 2003;52: 1567–71. 10. Oberhuber G, Granditsch G, Vogelsang H. The histopathology of coeliac disease: time for a standardized report scheme for pathologists. Eur J Gastroenterol Hepatol 1999;11:1185–94. 11. Riestra S, Fernandez E, Rodrigo L, Garcia S, Ocio G. Prevalence of coeliac disease in the general population of northern Spain. Strategies of serologic screening. Scand J Gastroenterol 2000;35:398–402. 12. Farrell RJ, Kelly CP. Celiac sprue. N Engl J Med 2002;346:180–8. 13. Sollid LM. Molecular basis of celiac disease. Annu Rev Immunol 2000;18: 53–81. 14. Korponay-Szabo IR, Kovacs JB, Czinner A, Goracz G, Vamos A, Szabo T. High prevalence of silent celiac disease in preschool children screened with IgA/IgG antiendomysium antibodies. J Pediatr Gastroenterol Nutr 1999;28: 26–30. 15. Lenhardt A, Plebani A, Marchetti F, Gerarduzzi T, Not T, Meini A, et al. Role of human-tissue transglutaminase IgG and anti-gliadin IgG antibodies in the diagnosis of coeliac disease in patients with selective immunoglobulin A deficiency. Dig Liver Dis 2004;36:730–4. 16. Tommasini A, Not T, Kiren V, Baldas V, Santon D, Trevisiol C, et al. Mass screening for coeliac disease using antihuman transglutaminase antibody assay. Arch Dis Child 2004;89:512–5. 17. Picarelli A, Sabbatella L, Di Tola M, Gabrielli F, Greco R, Di Cello T, et al. Celiac disease diagnosis in misdiagnosed children. Pediatr Res 2000;48: 590–2.
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ورودعنوان ژورنال:
- Clinical chemistry
دوره 51 6 شماره
صفحات -
تاریخ انتشار 2005